Anika Noni Rose ...  Tiana (voice) 
 Bruno Campos ...  Prince Naveen (voice) 
 Keith David ...  Dr. Facilier (voice) 
 Michael-Leon Wooley ...  Louis (voice) 
 Jennifer Cody ...  Charlotte La Bouff (voice) 
 Jim Cummings ...  Ray (voice) 
 Peter Bartlett ...  Lawrence (voice) 
 Jenifer Lewis ...  Mama Odie (voice) 
 Oprah Winfrey ...  Eudora (voice) 
 Terrence Howard ...  James (voice) 
 John Goodman ...  'Big Daddy' La Bouff (voice) 
 Elizabeth Dampier ...  Young Tiana (voice) 
 Breanna Brooks ...  Young Charlotte (voice) 
 Ritchie Montgomery ...  Reggie (voice) 
 Don Hall ...  Darnell (voice) 
 Paul Briggs ...  Two Fingers (voice) 
 Jerry Kernion ...  Mr. Henry Fenner (voice) 
 Corey Burton ...  Mr. Harvey Fenner (voice) 
 Michael Colyar ...  Buford (voice) 
 Emeril Lagasse ...  Marlon the Gator (voice) 
 Kevin Michael Richardson ...  Ian the Gator (voice) 
 Randy Newman ...  Cousin Randy (voice) 
 Danielle Moné Truitt ...  Georgia (voice) 
 Keith Anthony ...  Additional Voices (voice) 
 Kwesi Boakye ...  Additional Voices (voice) 
 Roger Aaron Brown ...  Additional Voices (voice) 
 June Christopher ...  Additional Voices (voice) 
 David Cowgill ...  Additional Voices (voice) 
 Peter Del Vecho ...  Additional Voices (voice) 
 Terri Douglas ...  Additional Voices (voice) 
 Jeff Draheim ...  Additional Voices (voice) 
 Rob Edwards ...  Additional Voices (voice) 
 Eddie Frierson ...  Additional Voices (voice) 
 Bridget Hoffman ...  Additional Voices (voice) 
 Kelly Hoover ...  Additional Voices (voice) (as Kellie Hoover) 
 Rif Hutton ...  Additional Voices (voice) 
 Wolfgang Wesley Hutton ...  Additional Voices (voice) 
 Margaret Johnson-Holzendorf ...  Additional Voices (voice) 
 John Kassir ...  Additional Voices (voice) 
 Jennifer Kilger ...  Swooning Girl (voice) 
 Mona Marshall ...  Additional Voices (voice) 
 John Musker ...  Additional Voices (voice) 
 Allison Norman ...  Additional Voices (voice) 
 Phil Proctor ...  Additional Voices (voice) (as Philip Proctor) 
 Peter Renaday ...  Additional Voices (voice) 
 Lynwood Robinson ...  Additional Voices (voice) 
 Kimberly Russell ...  Additional Voices (voice) 
 Lorry Ann Shea ...  Additional Voices (voice) 
 Bruce W. Smith ...  Additional Voices (voice) 
 Elissa Sussman ...  Additional Voices (voice) 
 Fred Tatasciore ...  Additional Voices (voice) 
 Claudette Wells ...  Additional Voices (voice) 
 Marlon West ...  Travis (voice) 
 Joe Whyte ...  Additional Voices (voice) 
 Seth R. Williamson ...  Prince Ralphie (voice) 
 Shanda M. Williamson ...  Additional Voices (voice) 
 Shane R. Williamson ...  Additional Voices (voice) 
 Mick Wingert ...  Additional Voices (voice)