In Australia, the young Cody discovers that evil poacher Perceval McLeach has captured the magnificent eagle, Marahute. He manages to set her free- only to be kidnapped himself and see Marahute later recaptured. A frantic call for help goes out to the Rescue Aid Society, which sends Miss Bianca and Bernard to help Cody. The two are aided by Wilbur the albatross, Jake, a kangaroo mouse, and Frank, a frill-necked lizard. Together Cody and his animal friends outwit McLeach and free his animal prisoners-including Marahute.

The Rescuers Down Under is based on the characters from the hit 1977 Disney animated feature The Rescuers, which in turn was based on the novels Miss Bianca and The Rescuers, by Margery Sharp. The Rescuers Down Under is the first sequel ever made to a Disney animated feature.